Protriptyline hydrochloride

A tricyclic antidepressant

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库存: 现货

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5mg

￥325.00

260.00

- +
10mg

￥550.00

440.00

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25mg

￥1212.00

970.00

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50mg

￥2062.00

1650.00

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Background

Protriptyline is a tricyclic antidepressant.¹ It binds to the norepinephrine and serotonin (5-HT) transporters with K_d values of 1.41 and 19.6 nM, respectively. Protriptyline also binds to histamine H₁, muscarinic acetylcholine, and α₁-adrenergic receptors (K_ds = 25, 25, and 130 nM, respectively).² It inhibits norepinephrine uptake into rat whole brain and hypothalamic synaptosomes (IC₅₀s = 12 and 0.55 μM, respectively) and 5-HT uptake into rat whole brain synaptosomes (IC₅₀ = 5.5 μM).³ Protriptyline (1 mg/kg, i.v.) inhibits food-induced cataplexy in narcoleptic dogs.⁴ Formulations containing protriptyline have been used in the treatment of depression.

1.Tatsumi, M., Groshan, K., Blakely, R.D., et al.Pharmacological profile of antidepressants and related compounds at human monoamine transportersEur. J. Pharmacol.340(2-3)249-258(1997) 2.Richelson, E., and Nelson, A.Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitroJ. Pharmacol. Exp. Ther.230(1)94-102(1984) 3.Schacht, U., and Heptner, W.Effect of nomifensine (HOE 984), a new antidepressant, on uptake of noradrenaline and serotonin and on release of noradrenaline in rat brain synaptosomesBiochem. Pharmacol.23(24)3413-3422(1974) 4.Foutz, A.S., Delashaw, J.B., Jr., Guilleminault, C., et al.Monoaminergic mechanisms and experimental cataplexyAnn. Neurol.10(4)369-376(1981)