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  • A2AR-agonist-1
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A2AR-agonist-1

An agonist of adenosine A2A receptor and inhibitor of ENT1

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¥3737-22250
价格
2990-17800
A2AR-agonist-1的二维码

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  • 货号: ajce46216
  • CAS: 41552-95-8
  • 别名: JMF 1907
  • 分子式: C20H22N6O4
  • 分子量: 410.43
  • 纯度: >98%
  • 溶解度: DMSO: 10 mM
  • 储存: Store at -20°C
  • 库存: 现货

Background

A2AR agonist-1 is an agonist of the adenosine A2A receptor and an inhibitor of equilibrative nucleoside transporter 1 (ENT1; Kis = 4.39 and 3.47 ?M for the human receptor and guinea pig transporter, respectively).1 It decreases adenosine uptake by 80% in PC12 cells when used at a concentration of 61 ?M and increases brain levels of adenosine in a transgenic mouse model of Huntington’s disease when administered at a dose of 20 mg/kg.2 A2AR agonist-1 (0.11 mg/kg) also rescues motor performance and increases survival in a transgenic mouse model of Huntington’s disease.


1.Chen, J.-B., Liu, E.M., Chern, T.-R., et al.Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotectionChem. Med. Chem.6(8)1390-1400(2011) 2.Kao, Y.H., Lin, M.S., Chen, C.M., et al.Targeting ENT1 and adenosine tone for the treatment of Huntington's diseaseHum. Mol. Genet.26(3)467-478(2017)

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