YF-2

A HAT activator

原价

￥1625-16025

价格

￥ 1300-12820

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库存: 现货

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产品引用

货号: ajce46440
CAS: 1311423-89-8
别名:
分子式: C20H22ClF3N2O3
分子量: 430.85
纯度: >98%
溶解度: DMSO : ≥ 125 mg/mL (290.12 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

YF-2 is a histone acetyltransferase (HAT) activator.¹ It inhibits proliferation of CCRF-CEM, Hs 578T, A549, and U251 cancer cells (IC₅₀s = 88.7-286 ?M), as well as multidrug-resistant NCI/ADR-RES cells (IC₅₀ = 44.8 ?M). YF-2 (5 mg/kg) increases reduced acetylated histone H3 levels in a mouse of model of Alzheimer's disease induced by amyloid-β (1-42) . YF-2 (20 mg/kg) reduces contextual fear memory deficits in the transgenic APP/PS1 mouse model of Alzheimer's disease.

1.Feng, Y., Fa, M., Arancio, O., et al.Histone acetyltransferase activators and uses thereofUS20130121919A1(2013)

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生命科学

有机化学

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材料科学

YF-2

YF-2详情

Background