Antihistamine-1
Antihistamine-1是能够渗透血脑屏障的H1-抗组胺药(Ki=6.9nM),它也是CYP2D6和hERG通道的抑制剂，其IC50值分别为5.4和0.8μM。
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包装价格促销价数量
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1mg￥737.00590.00- +
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5mg￥1212.00970.00- +
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10mg￥2062.001650.00- +
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- 货号: ajce46524
- CAS: 1186430-60-3
- 别名:
- 分子式: C23H24FN5
- 分子量: 389.47
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
Antihistamine-1 (Compound 2) is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively[1].
[1]. Lavrador-Erb K, et al. The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia. Bioorg Med Chem Lett. 2010 May 1;20(9):2916-9.
