Methoxamine hydrochloride

Methoxaminehydrochloride是去甲肾上腺素能受体α1的激动剂。

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10mg

￥862.00

690.00

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50mg

￥1512.00

1210.00

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Background

Methoxamine hydrochloride is a noradrenergic α1 agonistsup>[1].

Methoxamine produces a dose-related increase in force development of the cat papillary muscle that was selectively blocked by alpha-adrenergic antagonists. This is suggestive evidence of the presence of alpha-adrenergic receptors in ventricular myocardium[1].Methoxamine greatly enhances bistable behavior in the decerebrate. Methoxamine approximately doubles the amplitude of IPIC without changing its onset voltage, its offset voltage, or its persistence[2].

[1]. Rabinowitz B, et al. Positive inotropic effects of methoxamine: evidence for alpha-adrenergic receptors in ventricular myocardium. Am J Physiol. 1975 Sep;229(3):582-5. [2]. Lee RH, et al. Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine. J Neurophysiol. 1999 May;81(5):2164-74.