β-Amino Acid Imagabalin Hydrochloride (PD-0332334) (PD-0332334) 是 α2δ 的配体;电压依赖性钙通道的亚基。
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β-Amino Acid Imagabalin Hydrochloride (PD-0332334) is a ligand for the α2δ subunit of the voltage-dependent calcium channel.
β-Amino Acid Imagabalin Hydrochloride had been in phase III clinical trials for the treatment of generalised anxiety disorders. However, this research has been discontinued[2]. β-Amino Acid Imagabalin Hydrochloride had been also in phase I clinical trials for the treatment of chronic kidney disease[3].
[1]. Birch M, et al. A Simplified Process for the Manufacture of Imagabalin Hydrochloride (PD-0332334), an α2δ-Ligand for the Treatment of Generalised Anxiety Disorder. Org. Process Res. Dev., 2011, 15 (6), pp 1358-1364
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