6-Methoxy-2-naphthoic acid (Naproxen impurity O)

An active metabolite of nabumetone

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100mg

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Background

6-methoxy-2-Naphthoic acid (6-MNA) is an active metabolite of the non-steroidal anti-inflammatory drug (NSAID) nabumetone .^1,2 It inhibits COX-1 and LPS-induced COX-2 activities in isolated human whole blood (IC₅₀s = 31.01 and 19.84 ?M, respectively).² 6-MNA is also a potential impurity in commercial preparations of naproxen.³

1.Ray, J.E., and Day, R.O.High-performance liquid chromatographic determination of a new anti-inflammatory agent, nabumetone, and its major metabolite in plasma using fluorimetric detectionJ. Chromatogr.336(1)234-238(1984) 2.Cryer, B., and Feldman, M.Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugsAm. J. Med.104(5)413-421(1998) 3.Hrk, M., Babu, K.S., Lanka, A.R.P., et al.Simultaneous estimation of related compounds in esomeprazole and naproxen tablets by using ion pair reverse phase HPLCInt. J. Pharm. Pharm. Sci.7(2)460-464(2015)