A NOX4 inhibitor
GLX-351322 is an inhibitor of NADPH oxidase 4 (NOX4; IC50 = 5 ?M).1 It is selective for NOX4 over NOX2 (IC50 = 40 ?M). GLX-351322 (10 ?M) reduces glucose-induced production of reactive oxygen species (ROS) and cytotoxicity in isolated human pancreatic islets. It decreases blood glucose levels in an intravenous glucose tolerance test in mice fed a high-fat diet when administered in the drinking water at an estimated dose of 3.8 mg/kg per day.
1.Anvari, E., Wikstr?m, P., Walum, E., et al.The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 miceFree Radic. Res.49(11)1308-1318(2015)
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