Chitosan oligosaccharide (COS) is an oligomer of β-(1?4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) a
Chitosan oligosaccharide (COS) is an oligomer of β-(1?4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK).
[1] Muanprasat C, et al. Pharmacol Ther. 2017 Feb;170:80-97.
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Animal experiment: |
Mice[2]Seven-week-old female hairless BALB/c mice (n=12), weighing approximately 16 g, are used. After a week of acclimation, the hairless mice are randomly divided into five groups of 6 mice per group: Normal control group (without UV irradiation but with double-distilled water treatment); Model group (UV irradiation with double-distilled water treatment); COS-L group, COS-M group and COS-H group (UV irradiation with 50 mg/mL, 100 mg/mL and 200 mg/mL COS treatment, respectively). For mice used for topical application, 100 μL are applied to each mouse dorsal skin every time after UV-radiation. The dorsal treated skin area of mice is carefully wiped with soft absorbent cotton soaked in distilled water, and then wiped with dry cotton before each UV-radiation to remove any remaining Chitosan oligosaccharide (COS)[2]. |
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参考文献: [1]. Muanprasat C, et al. Chitosan oligosaccharide: Biological activities and potential therapeutic applications. Pharmacol Ther. 2017 Feb;170:80-97 |
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