EP1013 (F1013)
EP1013 (F1013) (F1013) 是一种广谱 caspase 选择性抑制剂，用于 1 型糖尿病的研究。
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包装价格促销价数量
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1mg￥1200.00960.00- +
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5mg￥2375.001900.00- +
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10mg￥3737.002990.00- +
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50mg￥10587.008470.00- +
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100mg￥16950.0013560.00- +
- 货号: ajce47022
- CAS: 223568-55-6
- 别名: F1013
- 分子式: C18H23FN2O6
- 分子量: 382.38
- 纯度: ＞98%
- 溶解度: DMSO : ≥ 60 mg/mL (156.91 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.
EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversalrate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function[1].
[1]. Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes. 2008 Jun;57(6):1556-66.
