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  • L-873724
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L-873724

L-873724是一种有效、可口服、选择性、可逆的非碱性cathepsinK抑制剂,对cathepsinK,cathepsinS,cathepsinL,cathepsinB的IC50值分别为0.2,178,264和5239nM。L-873724抑制兔子cathepsinK的活性,IC50值为0.5nM,同时可抑制骨再吸收

原价
¥9175-54225
价格
7340-43380
L-873724的二维码

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  • 库存: 现货
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  • 货号: ajce47172
  • CAS: 603139-12-4
  • 别名:
  • 分子式: C23H26F3N3O3S
  • 分子量: 481.53
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

L-873724 is a potent, orally bioavailable, selective and reversible[2] non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively[1]. L-873724 also exhibits an IC50 of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption[2].


L-873724 (Compound 22) is a potent and selective non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L-873724 also shows IC50s of 95, 1221 and 4807 nM for Ramos cathepsin S, Hep G2 cathepsin L, Hep G2 cathepsin B[1]. L-873724 exhibits an IC50 of 0.5 nM for rabbit cathepsin K[2].


L-873724 is orally bioavailable, non-lysosomotropic, and efficacious in the rhesus monkey bone resorption model[1].


[1]. Li CS, et al. Identification of a potent and selective non-basic cathepsin K inhibitor. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1985-9. [2]. Zhuo Y, et al. Inhibition of bone resorption by the cathepsin K inhibitor odanacatib is fully reversible. Bone. 2014 Oct;67:269-80.

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