A metabolite of vitamin B1
Thiamine pyrophosphate (TPP) (chloride) is a metabolite of vitamin B1. It is a cofactor synthesized in the cytosol that is required for the activity of cytosolic transketolase and mitochondrial pyruvate, oxoglutarate, and branched-chain keto acid dehydrogenases.1 TPP (chloride) prevents hyperglycemia-induced retinopathy and desflurane-induced hepatotoxicity in rats.2,3
1.Hawkins, C.F., Borges, A., and Perham, R.N.A common structural motif in thiamin pyrophosphate-binding enzymesFEBS Lett.255(1)77-82(1989) 2.Cinici, E., Ahiskali, I., Cetin, N., et al.Effect of thiamine pyrophosphate on retinopathy induced by hyperglycemia in rats: A biochemical and pathological evaluationIndian J. Ophthalmol.64(6)434-439(2016) 3.Arslan, A., Kuyrukluyildiz, U., Binici, O., et al.Can thiamine pyrophosphate prevent desflurane induced hepatotoxicity in rats?Acta Cir. Bras.31(3)168-175(2016)
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