A CCR4 receptor antagonist
AZD 2098 is a CC chemokine receptor 4 (CCR4) antagonist.1 AZD 2098 inhibits CCL22-induced calcium flux in CHO cells expressing human recombinant CCR4 (IC50 = 31.6 nM) and CCL22- and CCL17-mediated Th2 cell chemotaxis (IC50 = 501.2 nM for both). AZD 2098 is selective for CCR4 over CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 up to 10 ?M in vitro. Administration of AZD 2098 (0.07-2.5 mg/kg, p.o.) to ovalbumin-sensitized, antigen-challenged rats reduces alveolitis and leukocyte infiltration in the lung in a dose-dependent manner.
1.Kindon, N.D., Andrews, G., Baxter, A., et al.Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonistsMed. Chem.8(9)981-986(2017)
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