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- Cyclooxygenase (COX)
- RWJ 63556
RWJ 63556
RWJ63556是一种可口服的COX-2selective/5-lipoxygenase抑制剂，具有抗炎活性。
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包装价格促销价数量
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1mg￥4275.003420.00- +
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5mg￥8562.006850.00- +
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10mg￥14400.0011520.00- +
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20mg￥25425.0020340.00- +
- 货号: ajce47868
- CAS: 190967-35-2
- 别名:
- 分子式: C11H10FNO3S2
- 分子量: 287.33
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.
RWJ 63556 is a potent inhibitor of leukocyte influx over a period of 24 hr and maintains its in vitro profile on eicosanoids[1].
RWJ 63556 (1 mg/kg, i.v.) significantly inhibits the development of SP-induced oedema[2].
[1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. [2]. Le Filliatre G, et al. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001 Apr;132(7):1581-9.
