A pyran with diverse biological activities
Chelidonic acid is a pyran that has been found in C. majus and has diverse biological activities.1,2,3 It inhibits rat brain glutamate decarboxylase (Ki = 1.2 μM).2 Chelidonic acid (20 mg/kg per day) reduces serum IL-6 and TNF-α levels, colonic COX-2 and prostaglandin E2 levels, and the disease activity index score in a mouse model of ulcerative colitis induced by dextran sulfate sodium .1 It inhibits ovalbumin challenge-induced decreases in spleen IFN-γ levels and increases in serum, spleen, and nasal mucosa IgE levels, spleen IL-4 levels, and nasal mucosa eosinophil and mast cell infiltration in a mouse model of ovalbumin-sensitized allergic rhinitis when administered at a dose of 2 mg/kg.3
1.Kim, D.-S., Kim, S.-J., Kim, M.-C., et al.The therapeutic effect of chelidonic acid on ulcerative colitisBiol. Pharm. Bull.35(5)666-671(2012) 2.Porter, T.G., and Martin, C.L.Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylaseBiochem. Pharmacol.34(23)4145-4150(1985) 3.Oh, H.-A., Kim, H.-M., and Jeong, H.-J.Beneficial effects of chelidonic acid on a model of allergic rhinitisInt. Immunopharmacol.11(1)39-45(2011)
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