Chymase-IN-1
Chymase-IN-1是一个有效的，有选择性的，口服有活性的人肥大细胞糜蛋白酶抑制剂，其IC50值为29nM。
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包装价格促销价数量
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1mg￥14287.0011430.00- +
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5mg￥20662.0016530.00- +
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10mg￥37075.0029660.00- +
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- 货号: ajce48102
- CAS: 862090-74-2
- 别名:
- 分子式: C20H15ClNO4PS
- 分子量: 431.83
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.
Chymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM[1].
Chymase-IN-1 exhibits low oral bioavailability in rats (F=3%; oral t1/2=1.8 h)[1].
[1]. Greco MN, et al. Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50(8):1727-30.
