SC57666

SC57666是选择性的COX2抑制剂，IC50值为26nM。

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库存: 现货

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数量
1mg

￥3050.00

2440.00

- +
5mg

￥6037.00

4830.00

- +
10mg

￥10250.00

8200.00

- +
20mg

￥18700.00

14960.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM.

SC57666 inhibits COX2 with an IC50 of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC50=6000±1900 nM)[2].

SC57666 has been shown to be orally active (ED50=1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk[1].

[1]. Reitz DB, et al. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally activeCOX2 inhibitors. J Med Chem. 1994 Nov 11;37(23):3878-81. [2]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.