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- Cyclooxygenase (COX)
- COX/5-LO-IN-1
COX/5-LO-IN-1
COX/5-LO-IN-1是cylooxygenase和5-lipoxygenase的抑制剂，用于炎症性和过敏性疾病的研究。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥12075.009660.00- +
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5mg￥24150.0019320.00- +
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10mg￥41850.0033480.00- +
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20mg￥73337.0058670.00- +
- 货号: ajce48176
- CAS: 154355-75-6
- 别名: Atreleuton analog
- 分子式: C16H15FN2O2S
- 分子量: 318.37
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
COX/5-LO-IN-1 is an inhibitor of cylooxygenase and 5-lipoxygenase, used for the research of inflammatory and allergic disease states.
COX/5-LO-IN-1 reduces the biosynthesis of leukotrienes B4, C4, D4, and E4 and cyclooxygenase products such as prostaglandins and thromboxane and are useful in the treatment of inflammatory and allergic disease states[1]. COX/5-LO-IN-1 shows inhibitory activities against 5-lipoxygenase, with IC50 of 0.2 μM in human whole blood[2].
[1]. Lipoxygenase and cyclooxygenase inhibiting compounds. US 5516789 A [2]. Brooks CD, et al. (R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor. J Med Chem. 1995 Nov 24;38(24):4768-75.
