An aminomethylcycline antibiotic
Omadacycline is an aminomethylcycline antibiotic.1 It is active against tetracycline-susceptible and -resistant strains of S. aureus, E. faecalis, E. faecium, S. pneumoniae, and E. coli, as well as β-hemolytic streptococci (MICs = ≤0.06-2 ?g/ml). Omadacycline increases survival in mouse models of systemic infection with tetracycline-sensitive and -resistant strains of S. pneumoniae, S. aureus, or E. coli (ED50s = 0.3-3.34 mg/kg). Formulations containing omadacycline have been used in the treatment of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI).
1.Macone, A.B., Caruso, B.K., Leahy, R.G., et al.In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcyclineAntimicrob. Agents Chemother.58(2)1127-1135(2014)
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Animal experiment: |
Mice: Omadacycline is dissolved in sterile saline. Mice are infected using a 3-mL lock-top sterile syringe with a sterile 25-gauge, 5/8-in. needle. At 1 h postinfection (p.i.), mice are dosed intravenously (i.v.) with omadacycline or comparator compounds of interest at a volume of 10 ml/kg. A minimum of four dose levels are tested per experiment with 5 mice/group. The typical doses tested ranges from 0.11 to 18 mg/kg of body weight, with exceptions for comparators that requires significantly higher or lower doses to achieve 50% efficacy[1]. |
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参考文献: [1]. Macone AB, et al. In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline. Antimicrob Agents Chemother. 2014;58(2):1127-35. |
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