An aminoglycoside antibiotic
Bekanamycin is an aminoglycoside antibiotic.1 It is active against S. aureus, E. coli, P. aeruginosa, and P. rettgeri (MICs = 0.78-25 ?g/ml). Bekanamycin binds to the ribosomal decoding A site to interfere with bacterial protein synthesis.2
1.Umezawa, H., Umezawa, S., Tsuchiya, T., et al.3',4'-Dideoxy-kanamycin B active against kanamycin-resistant Escherichia coli and Pseudomonas aeruginosaJ. Antibiot. (Tokyo)24(7)485-487(1971) 2.Salian, S., Matt, T., Akbergenov, R., et al.Structure-activity relationships among the kanamycin aminoglycosides: Role of ring I hydroxyl and amino groupsAntimicrob. Agents Chemother.56(12)6104-6108(2012)
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