A macrolide antibiotic
Tylosin is a macrolide antibiotic produced by S. fradiae that has bacteriostatic activity against Gram-positive bacteria.1 It is a mixture of tylosin A, B, C, and D, with tylosin A contributing 80% of its bacteriostatic activity. Tylosin has MIC values of 9.6, 16.4, 0.1, 1, and 0.5 μg/ml for F. necrophorum, A. pyogenes, M. gallisepticum, S. aureus, and S. uberis, respectively.2,3,4 Formulations containing tylosin have been used for the prevention of liver abscesses in cattle.3 Tylosin is an environmental contaminant because it is not fully metabolized by treated livestock and enters the environment through manure-based fertilizers.5
1.Arsic, B., Barber, J., ?iko?, A., et al.16-membered macrolide antibiotics: A review.Int. J. Antimicrob. Agents30238-30280(2017) 2.Bonnier, M., Doré, C., Amédéo, J., et al.In vitro activity of tylosin and tilmicosin against cocci isolated from bovine mastitisRevue Méd. Vét.157(10)486-489(2006) 3.Nagaraja, T.G., and Chengappa, M.M.Liver abscesses in feedlot cattle: A reviewJ. Anim. Sci.76(1)287-298(1998) 4.Jordan, F.T., and Knight, D.The minimum inhibitory concentration of kitasamycin, tylosin and tiamulin for Mycoplasma gallisepticum and their protective effect on infected chicksAvian Pathol.13(2)151-162(1984) 5.Washington, M.T., Moorman, T.B., Soupir, M.L., et al.Monitoring tylosin and sulfamethazine in a tile-drained agricultural watershed using polar organic chemical integrative sampler (POCIS)Sci. Total. Environ.612358-367(2017)
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