An antiparasitic agent
Fexinidazole is an antiparasitic agent.1 It is active against 15 strains of T. brucei, including T. b. rhodesiense, T. b. brucei, and T. b. gambiense (IC50s = 0.95-3.31 ?M). Fexinidazole inhibits the growth of L. donovani at the promastigote and axenic amastigote stages (EC50s = 5.6 and 2.8 ?M, respectively).2 Fexinidazole (50 to 30 mg/kg per day) reduces parasitic burden and increases survival in a mouse model of infection with benznidazole-susceptible, -partially resistant, or -resistant T. cruzi.3 Formulations containing fexinidazole have been used in the treatment of African sleeping sickness and Chagas disease.
1.Su, L., Pan, P., Yan, P., et al.Role of vimentin in modulating immune cell apoptosis and infammatory responses in sepsisSci. Rep.9(1)5747(2019) 2.Wyllie, S.G., Patterson, S., Stojanovski, L., et al.The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasisSci. Transl. Med.4(119)119re111(2012) 3.Bahia, M.T., de Andrade, I.M., Martins, T.A.F., et al.Fexinidazole: A potential new drug candidate for Chagas diseasePLoS Negl. Trop. Dis.6(11)e1870(2012)
动态评分
0.0