A prodrug form of cephamandole
Cefamandole nafate is a formate ester prodrug form of the cephalosporin antibiotic cefamandole .1 Cefamandole nafate inhibits the growth of E. cloacae, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. aureus, and S. pyogenes in vitro (MICs = 0.1-50 μg/ml). In vivo, cefamanadole nafate protects against E. cloacae, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. aureus, and S. pyogenes infection in mice (ED50s = 0.3-334 mg/kg). Cefamandole (500 mg/kg) also protects against nephrotoxicity induced by the aminoglycoside antibiotic tobramycin in rats.2
1.Miller, A.K., Celozzi, E., Pelak, B.A., et al.Correlation of in vitro susceptibility with in vivo efficacy in mice for cefoxitin in comparison with cephalosporinsJ. Antimicrob. Chemother.5(5)569-579(1979) 2.Wold, J.S., Turnipseed, S.A., Broddle, W.D., et al.Effect of cefamandole nafate on the toxicity of tobramycinAntimicrob. Agents Chemother.12(4)465-469(1977)
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