A STING activator
DSDP is an activator of stimulator of interferon genes (STING).1 It induces expression of an IFN-stimulated gene 54 (ISG54) luciferase reporter in HepAD38 cells that constitutively express human cyclic GMP-AMP synthase (cGAS) and STING. DSDP (50 ?M) increases IFNB1, TNFA, and IL29 expression in HepG2 cells expressing wild-type human, but not C-terminal truncated human or mouse, STING, as well as in isolated human peripheral blood mononuclear cells (PBMCs). It inhibits yellow fever, dengue, and Zika virus replication in THF fibroblasts at the same concentration.
1.Liu, B., Tang, L., Zhang, X., et al.A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonistsAntiviral Res.14737-46(2017)
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