A semi-synthetic β-lactam antibiotic
Ticarcillin is a semisynthetic β-lactam antibiotic.1,2 It is active against P. aeruginosa, E. coli, P. mirabilis, P. rettgeri, and K. aerogenes (MICs = 4-125 μg/ml).2 Topical administration of ticarcillin (2.5 mg per eye) reduces P. aeruginosa colony count in rabbit eye.1 Formulations containing ticarcillin have been used in the treatment of a variety of bacterial infections.
1.Ahmad, A., Smolin, G., Okumoto, M., et al.Ticarcillin in the treatment of experimental pseudomonas keratitisBr. J. Ophthalmol.61(2)92-95(1977) 2.Comber, K.R., Basker, M.J., Osborne, C.D., et al.Synergy between ticarcillin and tobramycin against Pseudomonas aeruginosa and Enterobacteriaceae in vitro and in vivoAntimicrob. Agents Chemother.11(6)956-964(1977)
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