An insecticidal antibiotic
Milbemycin oxime is a semisynthetic macrocyclic lactone prepared by the oxidation and oximation of an 80:20 ratio of milbemycin A3 and A4 . Like other milbemycin/avermectins, it can potentiate glutamate and GABA-gated chloride-channel opening and is used as a nematocide and insecticide in veterinary medicine.1,2
1.Duke, S.O., Cantrell, C.L., Meepagala, K.M., et al.Natural toxins for use in pest managementToxins (Basel)2(8)1943-1962(2010) 2.Bienhoff, S.E., Kok, D.J., Roycroft, L.M., et al.Efficacy of a single oral administration of milbemycin oxime against natural infections of Ancylostoma braziliense in dogsVet. Parasitol.195(1-2)102-105(2013)
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