Cefmenoxime hydrochloride (Cefmenoxime hemihydrochloride)

A cephalosporin antibiotic

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库存: 现货

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100mg

￥375.00

300.00

- +
500mg

￥1075.00

860.00

- +

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Background

Cefmenoxime is a broad-spectrum cephalosporin antibiotic.¹ It is active against clinical isolates of S. aureus, S. epidermidis, S. pyogenes, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. marcescens, and E. cloacae in vitro (MICs = 0.013-6.25 μg/ml). It is active against various Gram-positive and Gram-negative bacterial infections in mice (ED₅₀s = 0.016-66 mg/kg). It increases survival in a mouse model of K. pneumoniae infection with a 50% survival dose (SD₅₀) value of 7.6 mg/kg. Cefmenoxime is curative in a mouse model of P. mirabilis urinary tract infection with curative dose (CD₅₀) values ranging from 0.4 to 0.75 mg/kg. Formulations containing cefmenoxime have been used to treat various bacterial infections.

1.Tsuchiya, K., Kondo, M., Kida, M., et al.Cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin: In vitro and in vivo antibacterial activitiesAntimicrob. Agents Chemother.19(1)56-65(1981)