A broad-spectrum aminoglycoside antibiotic
Sisomicin is a broad-spectrum aminoglycoside antibiotic originally isolated from M. inyoensis.1 It is active against Gram-positive and Gram-negative bacteria including B. subtilis, S. aureus, E. coli, and P. aeruginosa among others (MICs = 0.01-0.75 ?g/ml) but is less active against P. multocida and V. coli (MICs = 7.5 and 2.4 ?g/ml, respectively). Sisomicin is protective against Gram-positive and Gram-negative bacterial infections in mice with 50% protective dose (PD50s) values ranging from 0.5 to 6 mg/kg.
1.Weinstein, M.J., Marquez, J.A., Testa, R.T., et al.Antibiotic 6640, a new Micromonospora-produced aminoglycoside antibioticJ. Antibiot. (Tokyo)23(11)551-554(1970)
动态评分
0.0