A prodrug form of ampicillin
Hetacillin is a prodrug form of the broad-spectrum antibiotic ampicillin .1 It is converted to ampicillin via hydrolysis. Hetacillin is active against several bacteria, including E. coli, S. typhimurium, S. flexneri, H. influenzae, and S. pneumoniae (MICs = 2.5, 1.25, 2.5, 0.5, and 0.05 ?g/ml, respectively). Intramammary administration of hetacillin increases the cure rate of bacterial infections in dairy cows.2 Formulations containing hetacillin have been used in the treatment of bovine mastitis.
1.Sutherland, R., and Robinson, O.P.W.Laboratory and pharmacological studies in man with hetacillin and ampicillinBr. Med. J.2(5555)804-808(1967) 2.Vasquez, A.K., Nydam, D.V., Capel, M.B., et al.Randomized noninferiority trial comparing 2 commercial intramammary antibiotics for the treatment of nonsevere clinical mastitis in dairy cowsJ. Dairy Sci.99(10)8267-8281(2016)
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