Cicloprolol hydrochloride

Cicloprolol是部分β1-肾上腺素能受体(β1-adrenoceptor)激动剂。

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库存: 现货

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1mg

￥6200.00

4960.00

- +
5mg

￥12175.00

9740.00

- +
10mg

￥20762.00

16610.00

- +
20mg

￥36562.00

29250.00

- +

已选 0 种 0 瓶

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Background

Cicloprolol is a partial β 1-adrenoceptor agonist .

Cicloprolol is a partial β1-adrenoceptor agonist considered for the treatment of patients with coronary artery disease and impaired left ventricular function[1]. The new β-adrenoceptor partial agonist Cicloprolol acts as a β-agonist at normal levels and as a β-antagonist at high levels of adrenergic discharge. Treatment with Cicloprolol should protect the heart against excessive stimulation, while providing a baseline level of sympathetic drive. Cicloprolol has a weak β1-agonistic effect at normal levels of adrenergic discharge and acts as an antagonist at high levels of discharge[2].

[1]. Weber S, et al. Pharmacodynamic without pharmacokinetic interaction between cicloprolol, a partial beta 1-adrenoceptor agonist, and digoxin in healthy subjects. Br J Clin Pharmacol. 1990 Sep;30(3):411-6 [2]. Cocco G, et al. An evaluation of the safety of the beta-modulator cicloprolol in chronic heart failure. Clin Cardiol. 1992 Jan;15(1):38-42.