- 首页
- CXCRs (CXC chemokine receptors)
- AZD-5069
AZD-5069
A CXCR2 antagonist
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
1mg￥650.00520.00- +
-
5mg￥987.00790.00- +
-
10mg￥1625.001300.00- +
-
25mg￥3162.002530.00- +
-
50mg￥4850.003880.00- +
-
100mg￥9175.007340.00- +
已选
0
种
0
瓶
金额:
￥0.00
首页
收藏
- 货号: ajce49656
- CAS: 878385-84-3
- 别名:
- 分子式: C18H22F2N4O5S2
- 分子量: 476.52
- 纯度: ＞98%
- 溶解度: DMSO : 90 mg/mL (188.87 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
AZD 5069 is an antagonist of chemokine receptor 2 (CXCR2; IC50 = 0.79 nM in a radioligand binding assay).1 It inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1, respectively). AZD 5069 (3 and 10 μmol/kg) inhibits bronchoalveolar lavage fluid (BALF) neutrophil influx in a rat model of LPS-induced lung neutrophilia and non-allergic airway inflammation.
1.Nicholls, D.J., Wiley, K., Dainty, I., et al.Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonistJ. Pharmacol. Exp. Ther.353(2)340-350(2015)
