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A CXCR2 antagonist
AZD 5069 is an antagonist of chemokine receptor 2 (CXCR2; IC50 = 0.79 nM in a radioligand binding assay).1 It inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1, respectively). AZD 5069 (3 and 10 μmol/kg) inhibits bronchoalveolar lavage fluid (BALF) neutrophil influx in a rat model of LPS-induced lung neutrophilia and non-allergic airway inflammation.
1.Nicholls, D.J., Wiley, K., Dainty, I., et al.Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonistJ. Pharmacol. Exp. Ther.353(2)340-350(2015)
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