现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • ML364
ML364的可视化放大

ML364

An inhibitor of USP2

原价
¥575-8787
价格
460-7030
ML364的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajce49682
  • CAS: 1991986-30-1
  • 别名:
  • 分子式: C24H18F3N3O3S2
  • 分子量: 517.54
  • 纯度: >98%
  • 溶解度: DMSO : ≥ 33 mg/mL (63.76 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

ML-364 is a reversible inhibitor of ubiquitin-specific protease 2 (USP2), a deubiquitinase, that has an IC50 value of 1.1 ?M in a fluorescence-based assay using di-ubiquitin substrates.1 It inhibits USP8, which is closely related to USP2, with an IC50 value of 0.95 ?M in the same assay. It has no activity at the proteases caspase-6, caspase-7, MMP-1, MMP-9, and USP15 or at 102 kinases in a panel including cell cycle regulators. ML-364 increases cyclin D1 degradation (IC50 = 0.97 ?M) in HCT116 colorectal carcinoma cells. It induces arrest of the cell cycle at the G1 phase in Mino mantle cell lymphoma and HCT116 cells and inhibits proliferation of HCT116 cells (IC50 = 3.6 ?M). It also decreases homologous recombination-mediated DNA repair in DR-GFP U2OS cells.


1.Davis, M.I., Pragani, R., Fox, J.T., et al.Small molecule inhibition of the ubiquitin-specific protease USP2 accelerates cyclin D1 degradation and leads to cell cycle arrest in colorectal cancer and mantle cell lymphoma modelsJ. Biol. Chem.291(47)24628-24640(2016)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服