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An IRAK-4 inhibitor
CA-4948 is an orally bioavailable inhibitor of interleukin-1 receptor associated kinase-4 (IRAK-4).1 It has antitumor activity in ABC-type diffuse large B cell lymphoma patient-derived xenograft (PDX) mouse models.
1.Booher, R.N., Samson, M.E., Xu, G.-X., et al.Abstract 1168: Efficacy of the IRAK4 inhibitor CA-4948 in patient-derived xenograft models of diffuse large B cell lymphomaCancer Res.77(13 Supp)1168(2017)
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