Corynoxine B
柯诺辛B(CorynoxineB)是吲哚生物碱天然化合物，一个beclin-1-dependent自噬诱导剂。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
5mg￥1562.001250.00- +
-
10mg￥2750.002200.00- +
- 货号: ajce49894
- CAS: 17391-18-3
- 别名: 柯诺辛碱 B
- 分子式: C22H28N2O4
- 分子量: 384.47
- 纯度: ＞98%
- 溶解度: DMSO: 83.33 mg/mL (216.74 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer. IC50 value:Target: Autophagy inducerin vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA-HMGB1 interaction [1].in vivo: Corynoxine B exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice [2].
[1]. Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10(1):144-54. [2]. Sakakibara I, et al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine. 1998 Apr;5(2):83-6.
