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  • PF-06873600
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PF-06873600

An inhibitor of Cdk2, Cdk4, and Cdk6

原价
¥5875-41850
价格
4700-33480
PF-06873600的二维码

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  • 库存: 现货
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  • 货号: ajce49906
  • CAS: 2185857-97-8
  • 别名: PF-3600
  • 分子式: C20H27F2N5O4S
  • 分子量: 471.52
  • 纯度: >98%
  • 溶解度: DMSO : 83.33 mg/mL (176.73 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (Cdk2), Cdk4, and Cdk6 (Kis = 0.13, 1.25, and 0.11 nM, respectively).1 It is selective for these CDKs over Cdk1 and Cdk9 (Kis = 4.5 and 19.6 nM, respectively). PF-06873600 inhibits the phosphorylation of RB transcriptional corepressor 1 (RB1) in, and the proliferation of, OVCAR-3 ovarian cancer cells (EC50s = 19 and 45 nM, respectively). In vivo, PF-06873600 (30 mg/kg) reduces tumor volume in CTG-0464 and CTG-01912 non-small cell lung cancer (NSCLC) patient-derived xenograft (PDX) mouse models.


1.Freeman-Cook, K.D., Hoffman, R.L., Behenna, D.C., et al.Discovery of PF-06873600, a CDK2/4/6 inhibitor for the treatment of cancerJ. Med. Chem.64(13)9056-9077(2021)

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