inS3-54A18

inS3-54A18 is a potent inhibitor of STAT3 with anti-cancer properties.

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库存: 现货

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数量
2mg

￥1200.00

960.00

- +
5mg

￥1712.00

1370.00

- +
10mg

￥2812.00

2250.00

- +
50mg

￥10162.00

8130.00

- +
100mg

￥16950.00

13560.00

- +

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Background

inS3-54A18 is a potent inhibitor of STAT3 with anti-cancer properties.

[1] Huang W, et al. Oncogene. 2016 Feb 11;35(6):783-92. doi: 10.1038/onc.2015.215.

Protocol

Animal experiment:

Briefly, 5×106 A549 cells are injected subcutaneously in the flanks of 5-6-week-old male NOD/SCID mice. When the tumor volume reach about 50.0?mm3, the mice are randomized using online program into two different groups (6/group) with one group treated by formulation vehicle control and the other by A18 at 200?mg/kg with oral dosing 2-3 times a week for 4 weeks. One mouse in each group dies during the study and is eliminated. Tumor volume and body weight of the remaining five mice in each group are measured twice a week without blinding. On the thirty-fifth day after implant, mice are euthanized and the tumor tissues are harvested and weighed. Necropsy is also performed to determine changes in the heart, lungs, kidneys, liver and spleen.

参考文献:

[1]. Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92