E3 ligase Ligand-Linker Conjugates 7

A VHL Ligand 1 derivative

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库存: 现货

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100mg

￥3737.00

2990.00

- +
500mg

￥14287.00

11430.00

- +
1g

￥26487.00

21190.00

- +
2g

￥37075.00

29660.00

- +

已选 0 种 0 瓶

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货号: ajce49974
CAS: 2064292-52-8
别名: VH032-PEG4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 4 hydrochloride; E3 ligase Ligand-Linker Conjugates 7
分子式: C32H50ClN5O8S
分子量: 700.29
纯度: >98%
溶解度: Water : 50 mg/mL (71.40 mM)
储存: Store at -20°C
库存: 现货

Background

VH 032 Linker 2 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1 . VH 032 Linker 2 comprises the von Hippel-Lindau (VHL) ligand domain and the polyethylene glycol (PEG) linker of the bromodomain and extra terminal (BET) inhibitor-containing PROTACs MZ2 and MZP-55.¹

1.Chan, K.H., Zengerle, M., and Ciulli, A.Impact of target warhead and linkage vector on inducing protein degradation: Comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffoldsJ. Med. Chem.61(2)504-513(2018)