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  • E3 ligase Ligand-Linker Conjugates 7
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E3 ligase Ligand-Linker Conjugates 7

A VHL Ligand 1 derivative

原价
¥3737-37075
价格
2990-29660
E3 ligase Ligand-Linker Conjugates 7的二维码

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  • 库存: 现货
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  • 货号: ajce49974
  • CAS: 2064292-52-8
  • 别名: VH032-PEG4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 4 hydrochloride; E3 ligase Ligand-Linker Conjugates 7
  • 分子式: C32H50ClN5O8S
  • 分子量: 700.29
  • 纯度: >98%
  • 溶解度: Water : 50 mg/mL (71.40 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

VH 032 Linker 2 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1 . VH 032 Linker 2 comprises the von Hippel-Lindau (VHL) ligand domain and the polyethylene glycol (PEG) linker of the bromodomain and extra terminal (BET) inhibitor-containing PROTACs MZ2 and MZP-55.1


1.Chan, K.H., Zengerle, M., and Ciulli, A.Impact of target warhead and linkage vector on inducing protein degradation: Comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffoldsJ. Med. Chem.61(2)504-513(2018)

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