Carcinoembryonic Antigen CEA

CarcinoembryonicAntigen(CEA)是大肠癌组织产生的一种糖蛋白，作为抗原可引起患者的免疫反应。CarcinoembryonicAntigen是一个广谱性肿瘤标志物。

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Background

Carcinoembryonic antigen (CEA) is a tumor marker in lung cancer.

Carcinoembryonic antigen (CEA) as tumor marker in lung cancer. The use of CEA as a prognostic and predictive marker. CEA is a glycoprotein involved in cell adhesion, and is normally produced during fetal development but the production stops before birth. CEA is a glycosyl phosphatidyl inositol (GPI)-cell surface anchored glycoprotein whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells[1].

[1]. Grunnet M, et al. Carcinoembryonic antigen (CEA) as tumor marker in lung cancer. Lung Cancer. 2012 May;76(2):138-43.