Corynoxine
An indole alkaloid
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包装价格促销价数量
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5mg￥1562.001250.00- +
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10mg￥2750.002200.00- +
- 货号: ajce50160
- CAS: 6877-32-3
- 别名: 柯诺辛
- 分子式: C22H28N2O4
- 分子量: 384.47
- 纯度: ＞98%
- 溶解度: DMSO : ≥ 100 mg/mL (260.10 mM);Water : < 0.1 mg/mL (insoluble)
- 储存: Store at -20°C
- 库存: 现货
Background
Corynoxine is an indole alkaloid that has been found in U. macrophylla and has neuroprotective activity.1,2 It increases levels of the autophagy marker LC3-II in Neuro2a and SH-SY5Y neuronal cells when used at concentrations ranging from 6.25 to 25 ?M.1 Corynoxine (25 ?M) increases degradation of wild-type and A53T mutant α-synuclein, a major component of Lewy bodies in the brain of Parkinson’s disease patients, in PC12 cells, an effect that can be reversed by the autophagy inhibitors 3-methyladenine and chloroquine . It reduces increases in methamphetamine-induced locomotor activity in rats when administered at doses of 30 and 100 mg/kg.2
1.Chen, L.-L., Song, J.-X., Lu, J.-H., et al.Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathwayJ. Neuroimmune Pharmacol.9(3)380-387(2014) 2.Sakakibara, I., Terabayashi, S., Kubo, M., et al.Effect on locomotion of indole alkaloids from the hooks of Uncaria plantsPhytomedicine6(3)163-168(1999)
