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Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) 是一种 PROTAC linker,属于 PEG 类。Cl-C6-PEG4-O-CH2COOH 可用于合成含氯烷烃的 PROTACs (HaloPROTACs)。
Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTACs (HaloPROTACs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.
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