AST2818 mesylate

An inhibitor of mutant EGFRs

原价

￥1850-13350

价格

￥ 1480-10680

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库存: 现货

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产品引用

货号: ajce50434
CAS: 2130958-55-1
别名: 甲磺酸伏美替尼; Furmonertinib mesylate; AST2818 mesylate
分子式: C29H35F3N8O5S
分子量: 664.7
纯度: >98%
溶解度: DMSO : 5 mg/mL (7.52 mM)
储存: Store at -20°C,unstable in solution, ready to use.
库存: 现货

Background

Aflutinib is an inhibitor of mutant EGFRs.¹ It is selective for EGFR^L858R, EGFR^G719X, EGFR^L858R, EGFR^L861A, and EGFR^T790M mutant EGFRs over wild-type EGFR. Aflutinib (10 and 30 mg/kg) reduces tumor growth in an EGFR^L858R and EGFR^T790M-expressing LU1868 non-small cell lung cancer (NSCLC) patient-derived xenograft (PDX) mouse model.

1.Shi, Y., Zhang, S., Hu, X., et al.Safety, clinical activity, and pharmacokinetics of alflutinib (AST2818) in patients with advanced NSCLC with EGFR T790M mutationJ. Thorac. Oncol.15(6)1015-1026(2020)

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生命科学

有机化学

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AST2818 mesylate

AST2818 mesylate详情

Background