A ROCK inhibitor
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ZINC00881524 is a Rho-associated kinase (ROCK) inhibitor.1 It decreases levels of ROCK1 in T47D and CAMA-1 breast cancer cells. ZINC00881524 decreases proliferation of T47D and CAMA-1 cells when used in combination with CNN1 knockdown.
1.Wang, Z., Li, T.-E., Chen, M., et al.miR-106b-5p contributes to the lung metastasis of breast cancer via targeting CNN1 and regulating Rho/ROCK1 pathwayAging (Albany NY)12(2)1867-1887(2020)
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