A chalcone and flavonoid with diverse biological activities
Bavachalcone is a polyketide synthase-derived chalcone and flavonoid that has been found in P. corylifolia and has diverse biological activities.1,2,3,4,5 It inhibits α-glucosidase and the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT1A7 (IC50s = 11.1, 11.3, and 3.6 ?M, respectively).2,3 Bavachalcone is cytotoxic to K562 chronic myeloid leukemia cells (IC50 = 2.77 ?M).4 It inhibits RANKL-induced osteoclastogenesis of isolated mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 5 ?g/ml.5
1.Zhou, K., Yang, S., and Li, S.-M.Naturally occurring prenylated chalcones from plants: Structural diversity, distribution, activities and biosynthesisNat. Prod. Rep.(2021) 2.Ryu, H.W., Lee, B.W., Curtis-Long, M.J., et al.Polyphenols from Broussonetia papyrifera displaying potent α-glucosidase inhibitionJ. Agric. Food Chem.58(1)202-208(2010) 3.Shan, L., Yang, S., Zhang, G., et al.Comparison of the inhibitory potential of bavachalcone and corylin against UDP-glucuronosyltransferasesEvid. Based Complement. Alternat. Med.958937(2014) 4.Wang, H.-M., Zhang, L., Liu, J., et al.Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogsEur. J. Med. Chem.92439-448(2015) 5.Park, C.K., Lee, Y., Chang, E.-J., et al.Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKLBiochem. Pharmacol.75(11)2175-2182(2008)
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