BAY-293

An inhibitor of the K-Ras-SOS1 protein-protein interaction

原价

￥2500-32062

价格

￥ 2000-25650

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库存: 现货

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产品引用

货号: ajce50614
CAS: 2244904-70-7
别名: (R)-6,7-二甲氧基-2-甲基-N-(1-(4-(2-((甲基氨基)甲基)苯基)噻吩-2-基)乙基)喹唑啉-4-胺
分子式: C25H28N4O2S
分子量: 448.58
纯度: >98%
溶解度: DMSO : ≥ 125 mg/mL (278.66 mM)
储存: Store at -20°C
库存: 现货

Background

BAY-293 is an inhibitor of the protein-protein interaction between K-Ras and the guanine nucleotide exchange factor son of sevenless homolog 1 (SOS1; IC₅₀ = 0.021 ?M).¹ It inhibits proliferation of K562 and MOLM-13 cells expressing wild-type K-Ras, as well as NCI H358 and Calu-1 cells expressing mutant K-Ras^G12C with IC₅₀ values of 1.09, 0.995, 3.48, and 3.19 ?M, respectively.

1.Hillig, R.C., Sautier, B., Schroeder, J., et al.Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interactionProc. Natl. Acad. Sci. USA116(7)2551-2560(2019)

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BAY-293

BAY-293详情

Background