A DUSP26 inhibitor
F1063-0967 is an inhibitor of dual-specificity phosphatase 26 (DUSP26; IC50 = 11.62 ?M).1 It induces IMR-32 neuroblastoma cell apoptosis (IC50 = 4.13 ?M).
1.Ren, J.-X., Cheng, Z., Huang, Y.-X., et al.Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular dockingBiomed. Pharmacother.89376-385(2017)
Cell experiment: | The IMR-32 cells are plated in 96-well plates with 1×103 cells per well. After the cells are allowed to settle for 24 h, F1063-0967 (0, 10, 1, and 0.1 μM) is added. An MTTassay is performed. For cell lines HL7702 and SH-SY5Y, the cells are allowed to settle for 24 h, F1063-0967 (10 μM) is added, then MTT assays are carried out after 72 h[1]. |
参考文献: [1]. Ren JX, et al. Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular docking. Biomed Pharmacother. 2017 May;89:376-385. | |
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