安捷凯在线客服
- 客服:
- 电话: 13061953619
- 微信:
An Mcl-1 inhibitor
ML-311 is an inhibitor of myeloid cell leukemia-1 (Mcl-1; IC50 = 0.31 ?M in a fluorescence polarization assay).1 It is selective for Mcl-1 over Bcl-xL (IC50 = >40 ?M). ML-311 decreases the proliferation of 13 cancer cell lines (EC50s = 0.3-25 ?M).
1.Richard, D.J., Lena, R., Bannister, T., et al.Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarkerBioorg. Med. Chem.21(21)6642-6649(2013)
动态评分
0.0