Trimethobenzamide hydrochloride (Ro 2-9578)

A dopamine D2 receptor antagonist and antiemetic

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库存: 现货

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数量
100mg

￥975.00

780.00

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200mg

￥1612.00

1290.00

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500mg

￥3225.00

2580.00

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Background

Trimethobenzamide is a dopamine D₂ receptor antagonist and antiemetic.¹ It prevents emesis induced by the dopamine agonist apomorphine in dogs when used at a dose of 20 mg/kg and stimulates contraction of isolated guinea pig ileum (ED₅₀ = 8.7 μg/mL).² Trimethobenzamide (20 mg/kg) decreases apomorphine-induced pecking responses in pigeons by 20% and increases the latent period of pecking from 4.3 to 8 minutes.³ Trimethobenzamide (6.7 g/kg per day for 2 weeks) enhances compensation and decreases recovery time from 70 to 32 weeks in unilaterally labyrinthectomized cats, a model of vestibular injury.⁴ Formulations containing trimethobenzamide have been used to treat nausea and vomiting.

1.Smith, H.S., Cox, L.R., and Smith, B.R.Dopamine receptor antagonistsAnn. Palliat. Med.1(2)137-142(2012) 2.Shallek, W., Heise, G.A., Keith, E.F., et al.Anti-emetic activity of 4-(2-dimethylaminoethoxy)-N-(3,4,5-trimethoxybenzoyl) benzylamine hydrochlorideJ. Pharmacol. Exp. Ther.126(3)270-277(1959) 3.Dhawan, B.N., Saxena, P.N., and Gupta, G.P.Antagonism of apomorphine-induced pecking in pigeonsBr. J. Pharmacol. Chemother.16(2)137-145(1961) 4.Peppard, S.B.Effect of drug therapy on compensation from vestibular injuryLaryngoscope96(8)878-898(1986)