An active metabolite of folic acid
Dihydrofolic acid is an active metabolite of folic acid and an intermediate in the biosynthesis of both purines and pyrimidines.1,2 It is formed via the NADH-dependent reduction of folic acid by dihydrofolate reductase (DHFR).2 Dihydrofolic acid (10, 50, and 100 ?g/ml) reduces insulin-like growth factor 1 receptor (IGF-1R) promotor activity in a cell-based reporter assay.3
1.Futterman, S.Enzymatic reduction of folic acid and dihydrofolic acid to tetrahydrofolic acidJ. Biol. Chem.228(2)1031-1038(1957) 2.López, C.A., and Menendez, J.C.AntimetabolitesMedicinal Chemistry of Anticancer Drugs9-52(2008) 3.Attias, Z., Werner, H., and Vaisman, N.Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent mannerEndocr. Relat. Cancer13(2)571-581(2006)
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