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  • 7-Methylguanine
7-Methylguanine的可视化放大

7-Methylguanine

A nucleotide metabolite

原价
¥637-637
价格
510-510
7-Methylguanine的二维码

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  • 库存: 现货
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  • 货号: ajce51474
  • CAS: 578-76-7
  • 别名: 7-甲基鸟嘌呤
  • 分子式: C6H7N5O
  • 分子量: 165.15
  • 纯度: >98%
  • 溶解度: 1 M NaOH: 50 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

7-Methylguanine is a metabolite of the natural purine base whose N9 position is available for chemical modifications.1 This genotoxic adduct can be generated by DNA methylation and has been used as a probe of protein-DNA interactions and for DNA sequencing methods.2 It is also considered to be a carcinogenic biomarker for cigarette smoking that is detectable in urine.3


1.Kozma, A., Ibá?ez, S., Silaghi-Dumitrescu, R., et al.7-Methylguanine: Protonation, formation of linkage isomers with trans-(NH3)2Pt(II), and base pairing propertiesDalton Trans.416094-6103(2012) 2.Lee, S., Bowman, B.R., Ueno, Y., et al.Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanineJ. Am. Chem. Soc.130(35)11570-11571(2008) 3.Lee, H.L., Hsueh, Y.M., Chung, C.J., et al.Correlation between the urine profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolites and N7-methylguanine in urothelial carcinoma patientsCancer Epigemiol. Biomarkers Prev.17(12)3390-3395(2008)

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