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1-甲基腺嘌呤是在N-1位被甲基取代的腺嘌呤,是 DNA 烷基化损伤的产物,可通过氧化去甲基化损伤逆转进行修复。
1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation.
[1]. Falnes P?, et al. Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins. Nucleic Acids Res. 2004 Dec 1;32(21):6260-7. Print 2004. [2]. Yang H, et al. Effect of 1-methyladenine on double-helical DNA structures. FEBS Lett. 2008 May 14;582(11):1629-33.
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